Application of Spherical Copper Oxide (II) Water Nano-fluid as a Potential Coolant in a Boiling Annular Heat Exchanger

Convective boiling heat transfer coefficient of spherical CuO (II) nanoparticles dispersed in water is experimentally quantified inside the vertical heat exchanger. Influence of different operating parameters including applied heat and mass fluxes, sub-cooling temperature and concentration of nano-fluid on forced convection and nucleate boiling heat transfer mechanisms is experimentally investigated and briefly discussed. Results show that by increasing heat and mass fluxes, the heat transfer coefficient considerably increases for both heat transfer regions, while by increasing the nanoparticle weight concentration, the heat transfer coefficient increases in convective heat transfer (about 35 % at the maximum concentration) and deteriorates the heat transfer coefficient (about 9 % at maximum concentration) in nucleate boiling region due to the formation of nanoparticle deposition on heating surface. Experimental results are then compared to well-known correlations. Results of comparisons reveal good agreement between experimental data and those obtained by some correlations. In addition, thermo-physical properties of CuO nano-fluid are experimentally measured and represented, which are a good reference for other nano-fluid-related studies

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational energy calculations on the structure of PNC-27 bound to HDM-2 suggest that 1:1 complexes form between PNC-27 and HDM-2 with the leader sequence pointing away from the complex. Immuno-scanning electron microscopy was carried out with cancer cells treated with PNC-27 and decorated with an anti-PNC-27 antibody coupled to 6 nm gold particles and an anti-HDM-2 antibody linked to 15 nm gold particles. We found multiple 6 nm- and 15 nm-labeled gold particles in approximately 1:1 ratios in layered ring-shaped structures in the pores near the cell surface suggesting that these complexes are important to the pore structure. No pores formed in the control, PNC-27-treated untransformed fibroblasts. Based on the theoretical and immuno-EM studies, we propose that the pores are lined by PNC-27 bound to HDM-2 at the membrane surface with the PNC-27 leader sequence lining the pores or by PNC-27 bound to HDM-2

Negated bio-events: Analysis and identification

Background: Negation occurs frequently in scientific literature, especially in biomedical literature. It has previously been reported that around 13% of sentences found in biomedical research articles contain negation. Historically, the main motivation for identifying negated events has been to ensure their exclusion from lists of extracted interactions. However, recently, there has been a growing interest in negative results, which has resulted in negation detection being identified as a key challenge in biomedical relation extraction. In this article, we focus on the problem of identifying negated bio-events, given gold standard event annotations.Results: We have conducted a detailed analysis of three open access bio-event corpora containing negation information (i.e., GENIA Event, BioInfer and BioNLP'09 ST), and have identified the main types of negated bio-events. We have analysed the key aspects of a machine learning solution to the problem of detecting negated events, including selection of negation cues, feature engineering and the choice of learning algorithm. Combining the best solutions for each aspect of the problem, we propose a novel framework for the identification of negated bio-events. We have evaluated our system on each of the three open access corpora mentioned above. The performance of the system significantly surpasses the best results previously reported on the BioNLP'09 ST corpus, and achieves even better results on the GENIA Event and BioInfer corpora, both of which contain more varied and complex events.Conclusions: Recently, in the field of biomedical text mining, the development and enhancement of event-based systems has received significant interest. The ability to identify negated events is a key performance element for these systems. We have conducted the first detailed study on the analysis and identification of negated bio-events. Our proposed framework can be integrated with state-of-the-art event extraction systems. The resulting systems will be able to extract bio-events with attached polarities from textual documents, which can serve as the foundation for more elaborate systems that are able to detect mutually contradicting bio-events. © 2013 Nawaz et al.; licensee BioMed Central Ltd

Experimental investigation on the pool boiling heat transfer to aqueous multi-walled carbon nanotube nanofluids on the micro-finned surfaces

Abstract not availableM.M. Sarafraz, F. Hormoz

Heat transfer, pressure drop and fouling studies of multi-walled carbon nanotube nano-fluids inside a plate heat exchanger

Abstract not availableM.M. Sarafraz, F. Hormoz

Thermal Performance and Viscosity of Biologically Produced Silver/Coconut Oil Nanofluids

In this work, thermal conductivity, viscosity, and boiling heat transfer coefficient of a biologically produced nano-coolant were experimentally quantified. The nanoparticles were produced from silver nitrate via the plant extraction method and by means of green tea leaf extract. The mean size of the particles was 50 nm, with spherical morphology and single-phase structure of Ag (silver). The synthesized particles were dispersed in coconut oil as base fluid. Thermal conductivity and viscosity of the nanofluid were experimentally measured and correlated based on temperature and concentration of nanoparticles via the regression analysis. Thermal performance of the nanofluid inside an annular heat exchanger with convective boiling conditions (in forced convection and nucleate boiling heat transfer regimes) was assessed. The results demonstrated a superior thermal performance in both heat transfer regions over the base oil, and revealed that this nanofluid can be used as a coolant as well as a lubricant in engines with high heat flux conditions, as its thermal conductivity and viscosity were enhanced due to the presence of Ag particles inside the oil

Comparatively experimental study on the boiling thermal performance of metal oxide and multi-walled carbon nanotube nanofluids

Abstract not available.M.M. Sarafraz, F. Hormoz

Experimental study on the thermal performance and efficiency of a copper made thermosyphon heat pipe charged with alumina-glycol based nanofluids

Abstract not available.M.M. Sarafraz, F. Hormo

Scale formation and subcooled flow boiling heat transfer of CuO-water nanofluid inside the vertical annulus

Abstract not availableM.M. Sarafraz, F. Hormoz